Tra i possibili approcci alla sintesi di questi composti noi abbiamo investigato la riduzione diastereoselettiva di N-sostituite (p-totil e tert-butil) piridil chetimmine con una serie di agenti riducenti (NaBH4, L-Selectride, DIBAL, 9-BBN) in diverse condizioni di reazione. That with low mollecular weight is preferably used and it has a few adverseĬhelucci, Giorgio Adolfo Baldino, Salvatore Pinna, Gérard Aimé Soccolini, FrancescoĪmmino piridine chirali hanno dimostrato la loro validità come leganti per la formazione di complessi metallici utilizzati nella catalisi asimmetrica. Another synthetic colloid is starch, which also has different mollecular weights. It lasts at about 4 hours in the vascular bed. It is derived from the bovine cartilage, although its indication in Cuba has decreased after the report of the mad cow disease. The gelatins are other group of synthetic colloids. At present, many authors do not recommend them due to the rheological complications appearing after their use. Those of low mollecular weight are the most used. There are dextrans with different mollecular weights. Nowadays, it is suggested the use of synthetic colloids for being safer compared with blood derivatives. La mezcla de soluciones es uno de los propósitos de la terapia actual.Volume replacement is a milestone in the treatment of patients with absolute hypovolemia. El reemplazo de volumen adecuado evita el fenómeno de hipovolemia asociado al de repercusión, por lo que debe ser utilizado de forma adecuada. Otro coloide sintético es el almidón, este también existe de varios pesos moleculares, preferiblemente se utiliza el de bajo peso molecular, y tiene pocas reacciones adversas.
Su tiempo en el lecho vascular dura alrededor de 4 horas. Las gelatinas son otro grupo de coloides sintéticos, la más utilizada en la actualidad es el gelafusin, que se deriva del cartÃlago bovino, aunque su indicación en Cuba ha disminuido después del reporte de la enfermedad de las vacas locas. Actualmente muchos autores no los recomiendan por las complicaciones reológicas que aparecen tras su uso. Los dextranos existen de varios pesos moleculares, y son los más utilizados los de bajo peso molecular. Actualmente se preconiza el uso de coloides sintéticos por ser más seguros en relación con los productos derivados de la sangre. Conclusions and an outlook on further research priorities are offered.Directory of Open Access Journals (Sweden)įull Text Available El reemplazo de volumen constituye un pilar en el tratamiento de los pacientes con hipovolemia absoluta. The state of the art of learning factories curricula design and their use to enhance learning and research as well as potentials and limitations are presented. An overview of existing learning factory approaches in industry and academia is provided, showing the broad range of different applications and varying contents. Definitions of the term learning factory and the corresponding morphological model are provided. The motivations, historic background, and the didactic foundations of learning factories are outlined. This paper intends to close this gap by establishing the state of the art of learning factories. While numerous learning factories have been built in industry and academia in the last decades, a comprehensive scientific overview of the topic is still missing.
#Bochum learning factory driver
Learning factories present a promising environment for education, training and research, especially in manufacturing related areas which are a main driver for wealth creation in any nation.
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